There are now 12 Smyths Toys superstores in the UK and this will represent the first store North of Birmingham for the group.
More northern based stores are planned for the new year. Current locations include many both north and south of London, Salisbury, two in Birmingham and Cardiff.
The new store is will be opening on Drakehouse retail Park in Sheffield before Christmas in time for the major campaigns that the company has planned to increase footfall.
A spokesman for Smyths commented: "We are delighted to announce the opening of our new store in in Sheffield. This is our first store in the North of England and we are excited to locate our store in this fantastic shopping destination, taking in both Drakehouse Retail Park and the nearby Crystal Peaks Shopping Centre. We hope to open early November and promise to offer customers an extensive range of high quality toys at competitive prices."