Ben Gordon will step down from his role as chief executive of Mothercare on November 17th.
Last week, Mothercare issued a profit warning after its UK sales dropped 9.6 per cent like-for-like in the third quarter. At the time Gordon said the retailer's domestic performance was 'well below' expectations.
Gordon spent nine years with the company.
He said: "I'm very proud of the Mothercare team and what we have built together.
"Mothercare is now one of the world's leading retail brands and has huge potential going forward. I wish the company all the best for the future."
As chief executive, Gordon played a key role in developing the maternity retailer's international business. Over the past year, sustained growth in foreign markets has helped Mothercare turn a profit despite falling sales at home.
Alan Parker, chairman of Mothercare, said: "We are grateful to Ben for the enormous change and improvement he has brought to Mothercare. On behalf of the Board, I want to thank Ben for his significant contribution to Mothercare and we wish him every success in the future."
Mothercare starts its search for a replacement immediately.