The range features Spider-Man and the Super Hero Squad, which airs on Nicktoons. Both sets are available now in counter display units.
Simon Philips, president, Worldwide Consumer Products for Marvel Entertainment, said: "We are all hugely excited about the prospect of seeing Spider-Man depicted in a Painting by Numbers sets.
"We are sure that they will appeal to thousands of fans and art enthusiasts around the world and we couldn’t think of a better, more highly respected brand to work with on this project than Reeves.
"The kits will also be out on the shelves in the same year as Marvel celebrates its 70th birthday, so we will be celebrating a special milestone in style with Reeves.”
Painting by Numbers product manager, Graham Curtis, revealed: "This is wonderful news for everyone connected with the brand and it is a great addition to the current range of pictures.
"Not only have we worked closely with Marvel for some months, but we have also conducted some research with a child development psychologist to ensure the Painting By Number products work for the targeted age groups.
"The research suggests that the age six-plus and eight –plus licences are the perfect fit, as the kits provide the ideal stimulant to keep children entertain and engaged, and leaving the child with a satisfied feeling when they have competed this picture.
"Not only is this great news for us all, it is a real success story for the industry and the wider business community, as the product will be manufactured here at our Kidderminster headquarters."