The redundancies, which will include some senior management positions, are being made in a bid to cut costs as the global financial situation slows consumer spending.
The workforce reductions represent about ten per cent of overall staff, the California-based company said in regulatory filings.
Martin Pidel, LeapFrog's executive vice president of international, has also resigned, effective December 1st, the company said.
LeapFrog, which expects the layoffs to be finalised in the first quarter of 2009, also plans to consolidate its headquarters operations.
The resulting reduction in costs is expected to be $8-9 million a year, the company said and it plans to take a related charge of about $5 million in the fourth quarter.
Severance payments should be "substantially" complete by the end of the third quarter of 2009 and payments associated with office space will be made over the next two years, the company said.