The retailer has signed a joint venture agreement with Goodbaby, a manufacturer of childcare products, to open three stores in Beijing and Shanghai next year.
The chain has more than 300 franchise stores in 39 countries, which account for one-third of group sales and more than 25 per cent of its profits.
"There are very few differences around the world for people preparing for the arrival of a baby," said Ben Gordon, chief executive of Mothercare.
The deal with Goodbaby will be give Mothercare 30 per cent of the equity with the remaining 70 per cent owned by Goodbaby.
Mothercare aims to build a presence across the Chinese mainland. In the longer term it may also take the Early Learning Centre brand there too.
The move into Chinese retailing comes after the firm opened a new Shanghai sourcing office.