Final of the national competition is set to take place on May 19th at John Lewis Stratford City.
The winner of the contest will receive a money can’t buy rowing experience with Olympian Sir Steve Redgrave - the official ambassador and face of the 2012 Top Trumps Schools Tournament - on the River Thames.
Sir Steve will also be present at the event and will officially crown the winner.
To reach the final, each of the 12 contestants had to first trump classmates at their school before winning through online competitions.
Fiona Hortopp, head of marketing at Winning Moves UK, commented: "Our hearty congratulations to all twelve. They have shown sheer class to reach the Grand Final. As far as we are concerned all 12 are winners already – having come out ahead of so many other school children across the country."
The National Children’s Bureau carried out detailed research on the National Schools Top Trumps Tournament and concluded the game helps children improve both numeracy and literacy.
“Its findings have resulted in heads and teachers seeing the advantage of bringing in Top Trumps as a teaching tool inside the classroom,” added Hortopp.
“This year’s tournament has also given schools up and down the country the opportunity to learn all about the Olympic and Paralympic games – past and present – which of course is so topical."
The finalists will compete with a special commemorative bumper ‘Tournament’ version of Top Trumps format, themed around the London 2012 edition of a brand new Top Trumps Tournament game, which features London 2012 medal hopefuls as well as scores of Olympians past and present.
In the ‘Olympic Moments’ cards theme a Usain ‘Bolt of Lightning’ card enables players to trump any opponent in the ‘Hall of Fame’ category.